A chance to support research on Parkinson's Disease

(by drugmonkey) Apr 23 2014

The scientist known as @parklifensci (Parklife blog) on the Internet will be walking in the Parkinson's Unity Walk. The donation page says:

Why I'm walking:
Every walker and donor makes a difference by taking the Walk one step closer to finding the cause and cure for Parkinson’s. By joining together with thousands of others, we'll be empowering those who are living with the disease, and honoring those who lived with Parkinson’s.

Who I’m walking for:
Over 1 million people in the United States have Parkinson’s. 60,000 people are newly diagnosed every year – one person, every nine minutes. Walking and raising funds and awareness for research is my chance to help.

Why I'm supporting the Parkinson’s Unity Walk:
100% of donations go to research. The Parkinson’s Unity Walk is the largest grassroots event in the U.S., raising funds and awareness for research.

Ways to support my fundraising efforts:
There's strength in numbers so please join me. Donate, register to walk, and fundraise.

I encourage you to donate if you can or join the walk if you are nearby.

No responses yet

"These forces are real and I had to survive them"

(by drugmonkey) Apr 22 2014

Neil DeGrasse Tyson on "The Larry Summers question: What's up with chicks in science?":

From a panel discussion hosted by the Center for Inquiry. Starts at 1:02:30 of the video.

10 responses so far

Your Grant in Review: The Biosketch Research Support Section

(by drugmonkey) Apr 21 2014

A question came up on the twitts about the Research Support section of the NIH Biosketch.

The answer is that no, you do not. I will note that I am not entirely sure if this changed over the years or if my understanding of this rule was incomplete at the start. However, the instructions on the Sample Biosketch [PDF] provided by the NIH are clear.

D. Research Support
List both selected ongoing and completed research projects for the past three years (Federal or non-Federally-supported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs.

The last bit is the key bit for Dr24Hour's question but I include the full description for a reason.

dr24Hours also asked:

and there was a followup to my initial negative response

Together, these questions seem to indicate a misunderstanding of what this section is for, and what it is trying to communicate.

Note the use of the term "selected" and "most relevant" in the above passage.

The Biosketch is, in total, devoted to convincing the reviewers that the PI and other Investigative staff have the chops to pull off the project under review. It is about bragging on how accomplished they all are. Technically, it is not even a full recitation of all the support one has secured in the past three years. This is similar to how the Peer-reviewed Publications section is limited to 15 items, regardless of how many total publications that you have.

Inclusion of items in the Research Support section is to show that the Investigators have run projects of similar scope with acceptable success. Yes, the definition of acceptable success is variable, but this concept is clear. The goal is to show off the Investigator's accomplishments to the best possible advantage.

The Research Support is not about demonstrating that the PI is successful at winning grants. It is not about demonstrating how big and well-funded the lab has been (no direct costs). It is not even about the reviewers trying to decide if the PI is spread too thinly (no listing of effort). This is not the point*.

In theory, one would just put forward a subset of the best elements on one's CV. The most relevant and most successful grant awards. If space is an issue (the Biosketch is limited to 4 pages) then the PI might have to make some selections. Obviously you'd want to start with NIH R01s (or equivalent) if the application is an R01. Presumably you would want to supply the reviewer with what you think are your most successful projects- in terms of papers, scientific advance, pizzaz of findings or whatever floats your boat.

You might also want to "selectively" omit any of your less-successful awards or even ones that seem like they have too much overlap with the present proposal.

Don't do this.

If it is an NIH award, you can be assured at least one of the reviewers will have looked you up on RePORTER and will notice the omission. If it is a non-NIH award, perhaps the odds are lower but you just never know. If the reviewer thinks you are hiding something...this is not good. If your award has been active in the past three years and is listed somewhere Internet-accessible, particularly on your University or lab website, then list it on the Biosketch.

Obviously this latter advice only applies to people who have a lot of different sources of support. The more of them you have, the tighter the space. Clearly, you are going to have to make some choices if your lab operates on a lot of different sources of support. Prioritize by what makes sense to you, sure, but make sure you pay attention to the communication you are trying to accomplish when making your selections. And beware of being viewed with a suspicion that you are trying to conceal something.
*Yes, in theory. I grasp that there will be reviewers using this information to argue that the PI is spread too thinly or has "too much" grant support.

10 responses so far

Job ad for Assistant Professor position makes it explicit...

(by drugmonkey) Apr 18 2014

Drexel University College of Medicine is hiring! ....sortof.

The Department of Neurobiology and Anatomy at Drexel University College of Medicine invites applications for a tenure-track Assistant or Associate Professor. We seek a SYSTEMS/BEHAVIORAL NEUROSCIENTIST whose research utilizes contemporary molecular, physiological and/or imaging techniques to address fundamental questions related to monoamine networks, cognitive function and motivated behavior, or psychostimulant drug actions. Applicants should have a Ph.D. in Neuroscience or a related field, a record of excellence in neuroscience research and publication, and preferably extramural funding (e.g., K99/R00 grant).

emphasis added. Unnecessarily.

Very interesting to see this when the drumbeat against soft-money faculty hiring and Med schools lust for indirect costs is getting louder.

h/t: @markgbaxter

24 responses so far

Thought of the Day: The NIH Can't Win

(by drugmonkey) Apr 18 2014

A comment over at Rock Talk made a fairly traditional complaint about the NIH funding system. Dan C stated that: "NIH is to be criticized that it funds “usual suspects.

Today, I find this funny. Because after all, most of the people complaining about the NIH system want to become one of the usual suspects!

Right? They want to get a grant, one. They want to have some reasonable stability of that grant funding in a program-like sustained career. Most of them don't want to have to struggle too hard to get that funding either....I doubt anyone would refuse the occasional Program pickup of their just-missed grant.

Once you cobble together a bit of success under the NIH extramural grant system, those who feel themselves to be on the outs call you a "usual suspect". For any number of reasons it is just obvious to them that you are a total Insider (and couldn't actually deserve what you've managed to accomplish, of course). This may be based on the mere fact that you've acquired a grant, because you work in a Department or University where a whole lot of other people are similarly successful. This may be because it appears that POs actually talk to the person in question. It may be because a FOA has appeared in a research domain that you work within.

Anyone sees the duck floating serenely on the water at a given point in time and it looks like this is one most usual suspect waterfowl indeed.

I used to be annoyed at my approximate lateral peers in science who appeared to be having an easier time of it than I did. I had my Insider attributes as a younger faculty member, make no mistake, but I also had considerable Outsider traits, considering where I was seeking funding and for what topics of research. Some of those folks, over there, well boy didn't they get an easy ride because of being such Insiders to the subpart of the NIH system!

I still have those thoughts. Even though I've seen many of the people I thought had it made in the shade go through their dry spells and funding down-cycles. Despite the fact that as each year goes by and my lab remains funded, I become more and more one of the "usual suspects".

I believe that if I ever feel like I am one of the usual suspects, if I feel like I deserve special treatment and stop fighting so hard to keep my lab going that this will be the end.

I advise you to try to retain the same feeling of "outsider" that you feel as a noob PI for as long as you can into your career.

Getting back to the point, however, the NIH simply cannot win with these criticisms. Those who are feeling unsuccessful will always carp about how the NIH just funds "their" people. And if the NIH does happen to fund one of these outsiders, this very act makes them a usual suspect to the next complainer.

The NIH can't win.

14 responses so far

Will You Be Attending Experimental Biology 2014?

(by drugmonkey) Apr 17 2014

The good folks at the American Society for Pharmacology and Experimental Therapeutics have seen fit to invite me to serve as an official blogger for the Experimental Biology 2014 meeting to be held in San Diego, CA, April 26-30. I will be joined in this effort by @katiesci who blogs at http://sicknessisfascinating.blogspot.com.

I would like to invite you, Dear Readers, to send me your presentation details, should you be attending this year. You can drop a note in the comments to this thread or send me an email (drugmnky at the google mail). I will try to stop by if it fits in my schedule and maybe blog it if I can understand what you do.

There may also be a meet up or two which revolves around either this community at the blog or my Twitter Tweeps. So stay in touch about that. If you are interested in such a thing and leave a comment, this may help to stimulate someone (say, me) to get off their behind and organize something.

Looking forward to seeing some of your science and to meeting some of you.

4 responses so far

NIH backs down on resubmitting unfunded A1 grant applications

(by drugmonkey) Apr 17 2014

The rumors were true. NOT-OD-14-074says:

Effective immediately, for application due dates after April 16, 2014, following an unsuccessful resubmission (A1) application, applicants may submit the same idea as a new (A0) application for the next appropriate due date. The NIH and AHRQ will not assess the similarity of the science in the new (A0) application to any previously reviewed submission when accepting an application for review. Although a new (A0) application does not allow an introduction or responses to the previous reviews, the NIH and AHRQ encourage applicants to refine and strengthen all application submissions.

So, for all intents and purposes you can revise and resubmit your failed application endlessly. Maybe they will pick you up on the A6 or A7 attempt!

Sally Rockey has a blog entry up which gives a bit more background and rationale.

While the change in policy had the intended result of a greater number of applications being funded earlier,

I really wonder if she believes this or has to continue to parrot the company line for face saving reasons. There is no evidence this is true. Not until and unless she can show definitively that the supposed A0s being funded were not in fact re-workings of proposals that had been previously submitted. I continue to assert that a significant number of PIs were submitting "A0" applications that were directly and substantially benefited by having been previously reviewed in different guise.

As a result, we heard increasing concerns from the community about the impact of the policy on new investigators because finding new research directions can be quite difficult during this phase of their career.

If the true concern here was the ESI or NI, then they could have simply allowed them to pass the filter as a category.

The resubmission of an idea as new means the application will be considered without an association to a previous submission; the applicant will not provide an introduction to spell out how the application has changed or respond to previous reviews; and reviewers will be instructed to review it as a new idea even if they have seen it in prior cycles.

The only way this is remotely possible is to put it in a different study section and make sure there are no overlapping ad hocs. If they don't do this, then this idea is nonsense. Surely Dr. Rockey is aware you cannot expect "instruction" to stick and force reviewers to behave themselves. Not with perfect fidelity.

However, we will monitor this new policy closely.

HA! If they'd decided to allow endless amendments (and required related apps to be submitted as such) then they would have been able to monitor the policy. The way they did this, there is no way to assess the impact. They will never know how many supposed "A0" apps are really A2, A4, A6, nor how many "A1" apps are really A3, A5, A7...etc. So what on earth could they possibly monitor? The number of established PIs who call up complaining about the unfundable score they just received on their A1?

69 responses so far

Side thought on the NIH issuing project grants versus program grants

(by drugmonkey) Apr 16 2014

I asked a poorly worded question on the Twitts

in which what I was trying to ask was this. From the perspective of awarding NIH grants, does it matter that a given proposal fits into a larger whole? If a brand new investigator, do we assume that he or she is applying for the first grant among many? For the greybeard for whom this might be a last-award, do we recognize that it is the capstone to a lengthy program? For the mid-career investigator do we assume this is only one of the many parts that will eventually form a large body of work?

Or is it all good if this is a singleton? One grant, awarded for 5 years and that is all.

The interesting thing is that nobody on the Twitts thought that I meant this. The answers went to various places- funding from non-NIH sources, relatively inexpensive research that didn't actually require an R01 to be vibrant, the idea of a single R01 that was continued beyond a mere 5 year interval. Many people assumed that what I was really talking about was assessing the merits and qualities of the PI.

After I got done kicking myself for not asking the question properly, a simple thought struck me.

Perhaps the very fact that people assumed I meant just about anything other than a single 5 year award, period, for a given PI was my answer. We do tend to expect that a R01 award fits into a larger research program. It does not stand alone as a single project.

19 responses so far

On 'Rescuing US biomedical research from its systemic flaws'

(by drugmonkey) Apr 14 2014

I was alerted on the Twitts

to a Perspective by Bruce Alberts (former Science EIC), Marc Kirschner (BSD), Shirley Tilghman (working tirelessly on "fix the NIH" committees) and Harold Varmus (former NIH Directior, current NCI Director). In Rescuing US biomedical research from its systemic flaws the authors recognize the current dismal state of affairs and issue several calls to action.

You will find nearly everything that has been put on the table here at this blog, at Rock Talking blog and, really, everywhere the discussions are serious about NIH-funded biomedical research. I find much to like in here and of course I disagree with several of their points and/or solutions.

Nevertheless, the overall goals are pretty good. They want to evolve to some more HHMI-like stability of funding, an equilibrium of participating scientists to the available budgets and to generally keep the grant process on improving scientific productivity rather than hampering it.

Overall there are good things being said here. But the specifics will be key. They argue for funding more graduate students on fellowships to give more control to the federal government. They phrase this in terms of "quality control" but they overlook using the bully pulpit to demand training programs actually reduce their output of PhDs! On the postdoctoral side of the over supply issue, they call for raising postdoctoral salaries until staff scientists are an attractive alternative. Then they call for increasing the ratio of staff scientist positions. I agree wholeheartedly but am not sure raising postdoc salaries is the way to go. There needs to be some additional mechanisms to provide a carrot to the expansion of the staff scientist category.

The Perspective also goes after the incentives local Universities, Med Schools and Research Institutes have to employ soft-money faculty. Proposals include going after soft-money job types, indirect cost recovery on faculty salary and some obscure but important stuff about including new construction costs in the IDC calculation.

Their recommendations for peer review changes are a mixed bag. They want to dismantle geographical diversity requirements for study section panels (O Rly?) and increase the number of oldsters on the panels. There is some of the usual blah-blah about risk taking, innovation, longer term outcome expectation and identifying the "strongest candidates for support".

What I don't like about these proposals is the stench of elitism that encircles them. As I have said repeatedly, one of the design virtues (even if imperfectly realized) of the NIH system is the respect for the democracy of ideas. In theory, anyone can propose a fundable study by coming up with a great idea that simply must be done. The alternative that is being proposed here is that we select good scientists at the beginnings of their careers and that is it. They get the money even if someone else has a better idea. Because that someone else may not have been selected in the beginning and will now never be able to get into the racket.

The racket will be dominated by pedigree, you better believe it. Not good.

There is one statement about peer review that I find hilarious:

Senior scientists with a wide appreciation for different fields can play important roles by counteracting the tendency of specialists to overvalue work in their own field.

...because "senior scientists" never "overvalue work" based on their biases, right? Please. I've said this many times in the context of grant review. Everyone has biases. EVERYONE! The only tried and true solution is the competition of biases which requires diversity. We need junior scientists in the mix. We need people from a diversity of institution types. We need people of diverse backgrounds and interests. We need a diversity of scientific approaches, orientations and interests. All competing on a more or less equal footing. It is the only way to minimize biases of review.

UPDATE/PostScript: I think these authors also fall into the usual trap of thinking that they know who the best scientists are and that if we could just get the money in their hands then the best science would result. It is the trap of thinking we can actually predict where the advances will come from. Read the history of optogenetics. Did it require Deisseroth? Would we have gotten there eventually? Would Deisseroth even have been funded under the New World Order envisioned by the Alberts et al Perspective piece? Has the infinitely more translatably useful DREADD technology been underdeveloped because of the shadow cast by optogenetics? In the New World Order might DREADD have been prevented entirely?

45 responses so far

Anti-Slut-Shaming Feminism

(by drugmonkey) Apr 14 2014

I know I have a few card carrying feminist types in my audience so I have a question for them.

The anti-slut-shaming issue is, to my understanding, a defense of women wearing whatever the hell they want without fear of randoms treating them in any particular way for those choices.

To the extent we are talking about public behavior and events.....I get that.

Ix-nay on the blaming of rape victims on the basis of their clothing choices. Yep.

No discrimination in the workplace for such matters that are irrelevant to job performance. Sure.

"Dude, you need to control yourself". Totally down with that.


"If you react to the sartorial style of a woman with sexual interest, my friend, that is ALL about you and your perving. The person in question is not dressing that way to have any effect on random dudes. They are not doing this in the slightest, tiniest way to have an effect on anyone other then their own personal pleasure and entertainment."

Here is what is unclear to me, my feminist readers.

Do you REALLY believe this?

Or is this the kind of situation where you take an absurdly absolutist position so as to avoid the slightest toe-step down the slippery slope of victim blaming in the aforementioned public, vocational and/or criminal situations?

32 responses so far

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