Archive for the 'Diversity in Science' category

Women in the R00 phase don't apply for R01s as frequently as men

Sally Rockey:

A specific issue that recently has recently created interesting conversations in the blogosphere is whether female K99/R00 awardees were less likely to receive a subsequent R01 award compared to male K99/R00 awardees. We at NIH have also found this particular outcome among K99/R00 PIs and have noted that those differences again stem from differential rates of application. Of the 2007 cohort of K99 PIs, 86 percent of the men had applied for R01s by 2013, but only 69 percent of the women had applied.

She's referring here to a post over at DataHound ("K99-R00 Evaluation: A Striking Gender Disparity") which observed:

Of the 201 men with R00 awards, 114 (57%) have gone on to receive at least 1 R01 award to date. In contrast, of the 127 women with R00 awards, only 53 (42%) have received an R01 award. This difference is jarring and is statistically significant (P value=0.009).
...
To investigate this further, I looked at the two cohorts separately. For the FY2007 cohort, 70 of the 108 men (65%) with R00 awards have received R01 grants whereas only 31 of the 62 women (50%) have (P value = 0.07). For the FY2008 cohort, 44 of the 93 men (47%) with R00 awards have received R01s whereas only 22 of the 65 women (34%) have (P value = 0.10). The lack of statistical significance is due to the smaller sample sizes for the cohorts separately rather than any difference in the trends for the separate cohorts, which are quite similar.

And Rockey isn't even giving us the data on the vigor with which a R00 holder is seeking R01 funding. That may or may not make the explanation even stronger.

Seems to me that any mid or senior level investigators who have new R00-holding female assistant professors in their department might want to make a special effort to encourage them to submit R01 apps early and often.

13 responses so far

Guest Post: Gender Sensitivity in Neuroscience is a Work in Progress

This is a guest post from someone who wishes to remain anonymous.

 


 

This week, the Society for Neuroscience opened its website allowing attendees to book their hotels for their annual meeting. The timing was couldn’t have been worse for the Vanderbilt neuroscience community given that on Monday, a former graduate student of the program leveled a disturbing series of accusations against neuroscientist Aurelio Galli. At least 10 of the 60+ alleged events of harassment occurred at SfN meetings. The year before the defendant claims she was subject to harassment, The Society for Neuroscience named Vanderbilt their ‘Neuroscience Training Program of the Year’.

 

In a 20 million dollar harassment suit filled in Nashville, sordid details were laid out of alcohol fueled harassment both in the lab and at the Society for Neuroscience’s annual meetings in 2012 and 2013. The student, a recovering alcoholic, alleges she was subjected to unwelcome and embarrassing commentary from Galli about her perceived lesbianism, her sex life and her looks both in lab as well as in front of male professors.

 

Vanderbilt fired back saying they had investigated the claims and would vigorously defend themselves.  The medical center director and the chancellor were named as defendants, as were Mark Wallace, the head of the Vanderbilt Brain Institute and National Academy member and Chair of the Department of Molecular Biology and Physiology, Roger Cone. Wallace and Cone were included for their failure to act on the student’s claims and protect her career.

 

For those outside the field, the neuroscience community seems to be holding down opposite poles in gender and racial equality. The leadership of both the Journal of Neuroscience and the Society are enviably gender balanced in the last decade. SfN was one of the first national societies to initiate meaningful career-long mentorship for women and minorities. Thanks in part to this commitment, women constitute 50% of most neuroscience graduate training programs. The national attrition of women from academic science is also evident in Vanderbilt’s neuroscience program which has an all male leadership and > 30% of its training faculty as women. The vast majority of these female faculty members are assistant professors.

 

Sending a female graduate student from a heavily male influenced neuroscience graduate program to SfN would present many sources of potential conflict. The first SfN meeting the student claims she was harassed at was in New Orleans, a city proud of its tradition of asking women to show their breasts for beads.

 

The female graduate student alleges that at SfN, her PI required her to attend a cocktail party on a boat where senior male scientists “became intoxicated and were allowed to make romantic and sexual advances on the students”. <I’ll insert my editorial opinion that news does not surprise me especially in light of the report this week from Kate Clancy that the majority of women in her survey of field scientists say they have been harassed with more than 20% reporting that they have been assaulted.>

 

Why would anyone attend boat party or any other kind of party where alcohol is flowing freely and fun is a much more clear objective than science?   For many trainees, this is often the only chance they have to spend time talking to well-published PIs. Presumably, at a party like this, senior investigators would be amenable to laid back conversations with trainees providing a rare chance to judge the character of potential future mentors.

 

These parties are the products of the bygone era of much larger gatherings held a decade or more ago by men who were SfN officers and investigators. Hosts had ample institutional ‘slush’ funds and open bar was the norm. The fabled parties hosted by former Emory Psychiatry chairman Charlie Nemeroff were more or less the height of partying for many members.

 

While at Emory, Nemeroff managed to get millions in personal wealth by consulting for drug companies while also studying those drugs using funding for his lab from NIMH. This income presumably enabled him to host these lavish events. Nemeroff’s parties would often devolve into factions that went skinny-dipping, participated in drinking contests and unwelcome ass grabbing, and yes, accomplished some important networking.

 

From the Venderbuilt lawsuit, “networking” was the reported benefit Galli touted as a reason for the trainee to attend the boat party. Indeed, Galli trained at Emory from 1993-1995 while Nemeroff was there, so these kinds of parties probably did help him advance his career. The expectation that a female recovering alcoholic would likewise benefit underscores a clear cultural clash that needs to be addressed by both the Vanderbilt community and the Society for Neuroscience.

30 responses so far

NIH takes their Sex-Differences show on the road

May 21 2014 Published by under Diversity in Science, NIH, NIH Careerism, NIH funding

In my view, once it is on The News Hour then it is really news.

Nature published a commentary by NIH Director Francis S. Collins and NIH Office of Research on Women's Health Director Janine A. Clayton which warns us that the NIH will start insisting on the inclusion of more sex-difference comparisons. These are to extend from cells to animal models across many areas of pre-clinical work.

The NIH is now developing policies that require applicants to report their plans for the balance of male and female cells and animals in preclinical studies in all future applications, unless sex-specific inclusion is unwarranted, based on rigorously defined exceptions. These policies will be rolled out in phases beginning in October 2014, with parallel changes in review activities and requirements.

I cannot wait to see what the "rigorously defined exceptions" will be for several types of research in which I have an interest. Every rat self-admin study must now include both males and females? For all treatment conditions or will it be acceptable to just tack the sex-comparison on at the end?

Furthermore, the NIH will monitor compliance of sex and gender inclusion in preclinical research funded by the agency through data-mining techniques that are currently being developed and implemented. Importantly, because the NIH cannot directly control the publication of sex and gender analyses performed in NIH-funded research, we will continue to partner with publishers to promote the publication of such research results.

oooooh. "partner with publishers" eh? Of course this is because Clayton and Collins realize that higher JIF journals are entirely uninterested in things as pedestrian as sex-comparisons, particularly when the outcome of the study is "no difference". Which, btw, is one of the reasons nobody* wants to waste their precious time and grant money doing something as low-return as sex-comparisons. So somehow the NIH is going to lean on publishers to be...friendlier....to such work. I do hope they realize that this is not going to work. The contingencies are not going to change because the NIH asks. Now, if they actually went all in and dismantled GlamourMagScience culture by the judicious use of grant award, grant auditing and rules about the ratio of publications to effort expended... then we might see some progress. That will never happen and thus there will be no change in the publication contingencies that fight against sex-comparison studies.

Dr. Clayton went on The News Hour where Judy Woodruff asked her (and Phyllis Greenberger of Society for Women's Health Research) some pretty obvious questions. Woodruff wanted to know if there were any clear examples in which women were put at risk or their health suffered because of a lack of such research. She also wanted to know what the implications for research might be- would it be more difficult or more expensive. Finally, Woodruff asked if scientists would resist.

From the transcript:

JUDY WOODRUFF: But how hard is that? Does that mean — is it extra work, is it more expensive? What’s involved in making sure there’s a gender balance?

Now Greenberger snuck in a "Both" off camera but then Clayton went on to be ridiculous and fail to answer the question. The answer is indeed "both" and it is a serious one if the NIH expects to get results. It will be more expensive, progress will be slower and it will be "harder" in the sense of teasing out the right experimental designs and variables so that an interpretable result can be reached. It isn't rocket science, exactly, but it is harder.

JUDY WOODRUFF: Phyllis Greenberger, were there — were there actually individuals who were harmed or where help wasn’t delivered because the research was done only on males?

Greenberger totally walked around this one and Woodruff, to her credit, fronted Clayton with the same question a bit later. Clayton referred to heart attack warning symptoms in women that might differ from men...of course this has nothing whatever to do with preclinical research. Gaaah! So frustrating. Greenberger chimed back in with talk of drugs being removed from the market for adverse effects in women....with no indication that these were adverse effects that would have been identified in female-specific PREclinical research. C'mon NIH! If you are going to take a run at this, please prepare your argument!


JUDY WOODRUFF: And is that the reason that it wasn’t done earlier, Dr. Clayton, that there was just pushback in the scientific community?

The answer is illustrative of the problem at the NIH....

DR. JANINE CLAYTON: It’s hard to say. There are probably a lot of factors that are involved.

And what’s really important now is right now we have been able to put the focus on getting this as a priority. As Phyllis mentioned, the Society and other advocacy groups and scientists and others have talked about this in the past. In fact, we are supporting scientists who are doing this research, but it wasn’t enough of a priority. In some way, it was like a blind spot. Scientists weren’t thinking about it.

Yes, there are a lot of factors. They aren't all that complicated either, since they boil down to scientists who want to conduct sex-differences comparisons being able to win funding to do the work.

Clayton is right. The NIH does indeed support investigators doing sex-differences studies.Those scientists do not have a problem of "priority" from the perspective of their own intrinsic motivation.

PubMedSexDiffsWith respect to whether scientists resist, I enjoin you to go over to PubMed and type in Sex Differences and see what fill-in choices are offered to you. Click on several of these searches and see what you find. You will find funded projects in many of your favorite domains of interest. If you bother to click on the papers and look at the grant attributions, you may even find that many of these investigations were completed under NIH funding!

So when Clayton (and in the Commentary she is joined by Director Collins) claims it isn't a "priority", it seems misplaced to put this on the shoulders of extramural scientists.

If the NIH wants more sex-differences studies then they need to deploy their tastiest carrot to greater effect. Put out some Funding Opportunity Announcements and see what happens! Fund a few Supplements to the people who are already doing sex-comparisons! Pick up a few grants that missed the payline...again, from the people who are already proposing sex-comparisons!

And if you want to lure in new converts that you didn't get with an RFA or a Program Announcement? This is simple. Just put out a policy that any grant application with a credible stab at a sex-comparison component gets an extra 5 percentile points credit towards the payline for funding.

Just you wait and see how many sudden converts you make!

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*of the GlamourMag class investigator

20 responses so far

Grant Review Site Visits

...need to be ended.

They represent a huge risk for bias dependent on the personal characteristics of the investigators to rule the day.

Are you an older, white-haired, heteronormative appearanced, able-bodied picture of "Scientist and Professor"? Great!

Are you overweight? Do you stutter? Express unexpected gender presentation? Nonwhite? Female? Are your language skills less than native to the reviewer's ears? Too young? Too hot? Not hawt enough? .... Not so great.

Should your grant proposal be affected strongly by the direct face to face impression of these characteristics?

No.

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H/t: @jwoodgett

Update: See PDF for site visit procedures

21 responses so far

"These forces are real and I had to survive them"

Apr 22 2014 Published by under Diversity in Science, Underrepresented Groups

Neil DeGrasse Tyson on "The Larry Summers question: What's up with chicks in science?":

From a panel discussion hosted by the Center for Inquiry. Starts at 1:02:30 of the video.

11 responses so far

Amy March, Sister Bear, Lisa Simpson.....oh hell, just read

Over at Tenure, She Wrote today:

For although it is true that Amy is a bit of a conceited twit, I strongly object to the core messages in this little speech: don’t show off, even if that means no-one notices how awesome you are. It’s better to be overlooked than to be conceited.

Although I don’t remember Sister Bear being particularly braggy, a quick Google search turned up several hits for “Braggy Sister Bear,” including some actual pages of Berenstain Bear books.

As you may be aware, I have a nonzero number of mini-women in my household. As a parent who is around a fair number of both boys and girls in the elementary and secondary school ages I am constantly amazed. The level of organization, responsibility, on-task behavior....it is like they are different species. My wife or I remark to each other on at least a weekly basis "Why are men in charge again?"

The above mentioned blog entry may be relevant to the question so Go Read.

5 responses so far

This doesn't belong in science. At all.

Mar 21 2014 Published by under Academics, Anger, Diversity in Science

When I first started noticing the opportunity to submit a "Graphical Abstract" for my papers I was initially perplexed as to why I would bother. Then I realized that the Graphical Abstract (at Elsevier titles anyway) could be a way to get the primary data figure out in front of the paywall. So I thought maybe we should do that.

Some joker has apparently concluded that he should use the Graphical Abstract space for being a sexist jerk.

via Dr. Isis, via this article. Elsevier has promised to pull the image so it may not last at the journal link.

Hur, hur, dudes, hur, de-hur, de-hur.

As detailed by Dr. Zen, Pier Giorgio Righetti is an author on at least four articles with highly sexualized Graphical Abstracts. Professor Righetti apparently responded to a query about the wisdom of one of these images with:

I wonder if you have been trained in the Vatican. As you claim to be a professor of Physiology, let me alert you that this image is physiology at its best!

This sounds remarkably like Dario Mastripieri who famously lamented the lack of attractive "super-model type" women at the Annual Meeting of the Society for Neuroscience on his Facebook page. This sexualization of women in a professional scientific and/or academic context has to stop. This is harassment of women in science. It lets all women in this job sector know that these dudes, senior figures with some influence mind you, see them as nothing other than potential sexual conquests. It is unfair, it is rude, it is detrimental to science and it is utterly unacceptable.

Professor Righetti  is on the Editorial Board of several journals, including the offending Journal of Proteomics where he is listed as the expert under the heading of "Proteomics of Body Fluids and Proteomic Technologies". Eww.  And it gets better. @Drew_lab queried the Journal's EIC Juan Calvete and received a dispiriting response.

At least it wasn't a complete brush off such as Professor Righetti gave. But it isn't a whole lot better.

I hope to settle the case as soon as possible to devote to the lab, which is what should take me up most of the day.

...this translates in my ear to "this is some absolute triviality and sure, sure, we'll take down the images but really don't you people have better things to worry about?"

Not really, no. The EIC Calvete has himself identified why this is the case. All scientists would prefer to use their time and energy in ways that are devoted to lab business. Unfortunately, reality intervenes. And when male scientists are hitting on, slavering over, disrespecting, leering at, joking about and generally treating female scientists as property, this takes away from the energy the women (and indeed other men who have to witness this crap) have available to devote to science.

So what would really be great is if an EIC like Calvete identified this sort of inappropriate image (hint: it IS inappropriate, not "may be inappropriate") in advance and prevented it from being published in the first place. It would be great if authors such as Righetti avoiding submitting these things. It would be great if Professors like Mastripieri kept their nasty little observations locked up tight inside their own heads.

 

Now go read Isis' post. Reason #140 Why Sexist Bullshit in Academia is Not Okay

13 responses so far

Guest Post: BUILDing Diversity with Dollars: Can Grants Change Culture

This guest post is from @iGrrrl, a grant writing consultant. I think I first ran across her in the comments over at writedit's place, you may have as well. She brings a slightly different, and highly valuable, perspective to the table.


iGrrlCartoonThere was an old New Yorker cartoon of two people at a party, and one tells the other, "I'm a fiction writer in the grant-proposal genre." I hate putting fiction in grant applications, especially the type that will be due shortly in response to the Ginther report.

For those who have been worrying about their own grant applications, the Ginther report detailed the relationship of race and ethnicity to NIH grant funding at the R01 level, and NIH has created a few initiatives to try to change the pattern of lower success rates for African American applicants. In early April, the applications are due for the Building Infrastructure Leading to Diversity (BUILD) Initiative, which would fund large-scale projects within individual institutions, and the NIH National Research Mentoring Network (NRMN), which is designed to build a network of mentors. In other words, diversity interventions writ large, with millions of dollars behind them.

The NSF ADVANCE program started in a similar way, and some of the early ADVANCE projects included programs with a limited evidence base. The successes of components of these programs were variable, and the recent RFA included a social science research component to complement the required evaluation of ADVANCE-funded activity. It started with good intentions, and eventually became clear that more than good intentions were needed. Part of the NRMN announcement calls for pilot programs, but I would argue that in the first year, the network should do the social science work to consolidate the anecdotes African Americans tell about their mentoring experiences into hard data, so that the pilot programs can be based upon addressing the needs identified by African Americans who have been through, or training right now in, the current system.

At the recent AAAS meeting in Chicago there were sessions on building diversity in science. At one I learned that explicit bias has reduced in the last 30 years, but implicit bias hasn't. We think we have made progress, and that our conscious intentions are enough. But they clearly are not. Expecting trainees to overcome biased behaviors (to which the actors are blind) places an undue burden on those who are discriminated against. There are studies showing that education about implicit bias helps to reduce such biased behavior, but education attempts can also be done badly and backfire. As pointed out in a recent piece in Science by Moss-Racusin, et al., there is an evidence base now for doing intervention well. If NIH is putting money into large-scale intervention, I hope the existing science will be part of the applications, and expected by the reviewers.

I've spent a lot of my professional life working on exactly the kind of large, infrastructure-based grant application represented by the BUILD and NRMN programs. It is easy for PIs to make assumptions that interventions that sound good on paper will actually have any impact. My concern is that what will be proposed by the applicants to BUILD and NRMN may miss the strong social science work that exists, and that still needs to be done. In fact, some of the best research on effective mentoring is the business literature, a place where few biomedical scientists would think to look.

Grant applications shouldn't be pure fiction, but based on solid evidence. Every grant application represents a possibility, a reality, that could come to pass if the funds are awarded. In the mentoring literature, practices that improve the success for African Americans are often shown to improve the climate for everyone. There is an opportunity here for those in biomedicine to learn from other fields, to consider an evidence base that is outside their usual ken, and to improve the entire biomedical enterprise by improving the overall environment. I hope that those applying for BUILD and the NRMN include the social sciences, and even more importantly, include the voices and ideas of the very people these programs are meant to serve.

NIH has a long history of using dollars to encourage cultural change, with mixed results, because applicants can have varying levels of commitment to the NIH vision while being happy to take NIH dollars. The ADVANCE program at NSF had some hiccups as they worked out what worked to improve the climate for women in STEM. The leadership teams for BUILD and NRMN should include people with a deep knowledge of the research and scholarship on bias and on mentoring, and who can do the rigorous analysis of the current state of affairs for African Americans in biomedical science. I hope I'm wrong here in worrying that such people won't be included, but I've seen fiction in grant applications a few too many times.

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Faces of Neuroscience: Jean A. King, Ph.D.

JeanKing Dr. Jean A. King [webpage] is Vice-Chair of Research and Professor in the Department of Psychiatry at the University of Massachusetts Medical School [PubMed; CV]. She completed her PhD in 1988 at NYU in Neurophysiology and conducted postdoctoral training at Emory. Dr. King's research record is diverse but can be characterized as focusing on neuroendocrine systems, stress, aggression, fear and substance abuse. Her work has also focused on advancing noninvasive imaging techniques in animal models using magnetic resonance imaging, in addition to the papers she has credit on three patents for neuroimaging advances. Professor King is the Director of the Center for Comparative Neuroimaging within the UMass Medical School. A recent paper from her laboratory (open access) applies imaging techniques to investigate white matter structural integrity in the brains of nicotine addicted human subjects that are associated with measures of physical dependence.

Over the years Dr. King's work has been funded by the National Science Foundation and the National Institutes of Health (a RePORTER search illustrates her NIH funding history as a Principal Investigator).

As you would expect for a scientist of this caliber, her expertise has been sought by an array of journals to provide peer review of manuscripts and by the NIH to serve on many grant review panels. I can confirm that Professor King is an excellent and insightful reviewer of grant applications with a persuasive and often humorous demeanor. Her comments were invariable informative, particularly for noob-ish grant reviewers (ahem). Similarly, Dr. King has supervised numerous trainees, participated on many service committees for her University, for the NIH and for multiple academic societies or entities. She has additional service in nonacademic settings. In this record there is a strong addition of service on issues important to women in science and in careers, generally.

I thank you, Professor Jean A King, for your long commitment to advancing our understanding of the brain and of affective disorder.

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Disclaimer: I am professionally acquainted with Dr. King.

picture borrowed from http://www.umassmed.edu/Content.aspx?id=96786

Series Note: The Diversity in Science Blog Carnival was created by D.N. Lee of the Urban Science Adventures! blog. In early 2009 she issued a call for a new blog carnival celebrating diversity in science and hosted the inaugural edition. The Diversity in Science Carnival #2 was hosted at Thus Spake Zuska under the theme Women Achievers in STEM - Past and Present. Prior entries from me have focused on Laura O'Dell, Carl Hart, Chana Akins, Percy Julian, Jean Lud Cadet,  and Yasmin Hurd.

One response so far

Maybe the problem in NIH grant award is in topic diversity?

Jan 29 2014 Published by under Diversity in Science, Uncategorized

I had a thought occur to me over the past few days. It's been growing along at the back of my mind and is only partially crystallized.

What if PIs of a given class of interest, whether that be sex, ethnicity, nation of origin or whatever, are not randomly distributed across the various topic domains supported by the NIH? What if a PI of characteristic X tends to work on Topic B using Model M whereas a PI of characteristic Y tends to work on Topic A using Model H?

What if the funding rates for Topic X differed from those for Topic Y? Or if applications using Model M consistently succeeded differently compared with applications using Model H?

I didn't see any covariates for topic domain or even the funding IC in the Ginther report.

Surely someone at NIH is thinking about this. Surely?

I have two anecdotes for your consideration.

First, as with many areas of science, the ones dear to me suffer from a sex bias. There is a huge tendency to do the animal studies in male animals. Any study using female animals is very frequently a sex comparison study and is proposed explicitly or implicitly as a comparison with the default, i.e. male. I've talked about this before. The NIH also takes pains to fix the generalized reluctance via their most functional technique, the call for applications for a dedicated pool of money. In theory, the awarding of grants on sex-differences or on issues specific to women's health will then spur additional work. Perhaps create a sustained program or even a career of work on this topic.

My anecdote is that I've noticed over the years (possible confimation bias here) that women in my field have a greater representation than men in these sorts of studies. Sex-differences models and womans' health issues in my fields of interest seem to have women as the driving investigators more often than their overall representation.

If this generalizes, then we will want to know if the competitive success of such grant applications because of topic is contaminating our estimation of women PI's success.

The second anecdote is older and comes from my long history participating on the "Diversity" committees of various academic institutions. Back in the dark ages I recall an incident where a Prof in the experimental sciences had to go to war with a Dean who was in charge of undergraduate summer research funds for underrepresented individuals. The Prof had a candidate who wanted to work in the experimental science, but the awards were generally being made to kids who wanted to work on academic topics related to underrepresented groups. The Dean thought this was the most important thing to do. In this case the prof won his battle in the second year of trying, over the objections of the Dean. I keep in touch with some of my undergraduate professors and I can say that said undergrad went on to become a NIH funded investigator (who still fails to work on issues directly related to underrepresentation). I have no idea if any of the other underrepresented summer research students went on to glorious academic careers in their respective disciplines, perhaps they did. But this is not the point. The point is that perhaps I am a little too glib about the pipeline implications of Ginther. Perhaps the grooming of underrepresented minority undergrads for a career in academics is itself not topic neutral. And the shaping and shifting from that very early stage may dictate field of study and therefore the eventual success rate at the NIH game.

Assuming, of course, that Topic X enjoys differential success rate from Topic Y when the grants are under review at the NIH.

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Doctoral Degrees to African Americans by topic

36 responses so far

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