Depression: Part 1

Feb 09 2009 Published by under Neuroscience

I don't generally miss my old blog, per se. I do kind of miss the layout, and I'll admit my name was pretty cool. But really, when I miss anything, I miss my old basic science posts I wrote. And since basic science is one of the things I'm all about (along with weird and freaky science, historical science, and...well, stuff), I thought I would repost some of them here. Admittedly, I'm saving them as kind of a cheat. Sci's got a rather crazy spring semester, and reposting is a wonderful way to save 2-3 hours to do things like work. But also, they never really got a lot of attention on the old blog (Sci was blogging under the radar), and so I would like to bring them into the sun of Scienceblogs, there to get ripped apart and questioned by the ravening masses. I am always looking for ways in which to improve myself.
So here's the first one, the first in a trio of posts on clinical depression:


depression_small.jpg
(from the work of Richard Wilkinson)
There are lots of theories out there as to what constitutes depression, whether it is over- or under-diagnosed and over- or under-treated, what causes it, and whether we should just HTFU. Right now, depression is thought to occur in 21% of women and 13% of men worldwide, with 18 million people affected in the US (this is according to the lecture I had in 2006 on it, though other people say it's 8-17% of the total population). It's a big deal for research, depression is second leading cause of disability, and antidepressants are the third best-selling group of pharmocotherapies in the world. Not only that, the economic burden is 12.4 billion dollars a year in medical, psychiatric, and pharmacological care, and that's not counting decreased productivity, work absences, and mortality costs for depression-related suicides (well, ok, it's not that much when compared to the cost of the Iraq war). Regardless of its issues in modern society, depression is both a significant emotional and economic burden, and something that goes very far back in human history.
Major depression is also known as Major depressive disorder, unipolar depression, and clinical depression. Many people see references to depression in the behavior of King Saul (book of Samuel, Chronicles I, believed to have lived around 1000 BCE), and the Greeks certainly noted depression in some patients, calling it "melancholia". Theories about it ranged from the idea of the four humors (where depression was caused by an excess of black bile), to being possessed by spirits, to being hounded by your mortal sins (which, given the persistent feelings of guilt that many depressed people feel, is not so far-fetched). Now, of course, it is classified in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) as a psychiatric disorder which can result from life events, biological/genetic susceptibility, or a combination of the two.
Symptoms: It's not just about feeling "down"
Depression as a diagnosis can actually be broken down into typical and atypical clinical depression, as well as types of depression comorbid with other psychological disorders. The biggest psychological symptoms used for diagnosis of major depression are a major change in mood, persistent sadness (more than two weeks in duration), thoughts of worthlessness and excessive guilt, thoughts of death, and a symptom called anhedonia, which is a lack of pleasure in previously enjoyed activities.
But it's not all in your head. Major depression is characterized by physical manifestations as well. In typical (or agitated) clinical depression, the physical symptoms include (in general) insomnia, decreases in appetite and weight loss, fatigue, and psychomotor agitation. In atypical (or retarded) clinical depression (which may actually be just as common than typical depression), there is fatigue, excessive sleeping, increases in appetite, food consumption and weight gain, and slowness of movement. Both types show inability to concentrate, as well as withdrawal from social situations, family, and friends.
These diagnoses do not include bipolar disorders, which have components of severe depression as well as components of mania, or depression comorbid with other disorders such as anxiety (right now we think that 58% of people with clinical depression also suffer from anxiety). Symptoms of depression can also be caused by problems such as chronic pain, thyroid problems (like hypo- or hyper-thyroidism), HIV, or other chronic diseases, where long-term stress in the body can cause psychological disturbance.
The DSM IV has several kinds of depression listed:
melancholic features: insomnia and weightloss, guilt
atypical features: weight gain, sleeping, and perceived social rejection
psychotic features: including delusions and some hallucinations, though those are rare
postpartum: I'm sure you've heard of this one, depression following giving birth, right now doctors think it can stem from the massive hormonal and physical changes taking place
There are also several other diagnoses which are not classified as depression, but which have depressive features as part of them:
Bipolar: this is divided into types one (with mania) and two (with hypo-, or less, mania)
Dysthymia: chronic mild depression, where you have a depressed mood for at least TWO YEARS without any major depressive symptoms (like thoughts of death or guilt), you're just down all the time. This makes me think of Mr. Snuffleupagus from Sesame Street when I was a kid..."ooooooh dear..."
Recurrant brief depression: this is VERY brief, a few days or a week, but can occur as often as once a month. In women it's usually connected to the menstrual cycle.
Seasonal affective disorder: usually associated with winter, though it can be any season, this is depressed mood connected with specific times of year. Interestingly, Mary I (bloody Mary) of England probably suffered from seasonal affective disorder, which in her case occurred in the autumn.
Reactive depression: a psychological response to an outside stress, such as the loss of a loved one, moving to a new place where you don't know anybody, etc.
Depression can be episodic, constant, and recurring. But prognosis with continuing (even after the episode is over) psychotherapy and pharmaceuticals can be very good.
I want to end this part with a disclaimer: I am NOT a doctor. Hell, right now I'm not even a PhD. Thus, I cannot tell you whether or not you have depression, bipolar, or anything else. If you look at what I've listed and go "OMG, that's me!!", see your doctor first, and ask them.
Next up is part 2: different pharmacotherapies for depression.

7 responses so far

  • Donna B. says:

    "Symptoms of depression can also be caused by problems such as chronic pain, thyroid problems (like hypo- or hyper-thyroidism), HIV, or other chronic diseases, where long-term stress in the body can cause psychological disturbance."
    Stress is an interesting subject. I remember years & years ago reading a magazine article about stress that included a questionnaire asking about recent life events, including positive ones. If you checked off more than a stated number, you were probably stressed.
    I laughed it off because everyone I could think of (including me) could have checked off over half the events listed. I concluded that if everybody is stressed it's a normal state and lost all interest in reading about stress for some time after that.
    Since then, I've learned not to get my health and science info from silly magazines.

  • d p l says:

    "OMG, that's me!!"

  • Kemist says:

    Symptoms of depression can also be caused by problems such as chronic pain, thyroid problems (like hypo- or hyper-thyroidism)

    Oh yeah, it does. It was the symptom that made me suspect hypothyroidism for myself. The rest (dry, brittle hair that falls off, weight gain, extreme fatigue, loss of memory & concentration, abnormal menstrual cycles) were so gradual I couldn't even bring them up when I went to the doctor. I didn't even have goiter. But being transformed from a generally cheerful person to a constantly weeping wreck (for months) was something I just couldn't ignore.
    Just a simple TSH blood test to find out. And just a small synthroid pill to be litterally reborn.

  • Kelly says:

    Me too on the hypothyroidism causing depression and anxiety. For years I was on the highest allowable dose of Celexa, taking Valium and Xanax too. I gained over 80lbs due to the weight gain effect of the SSRI and the undiagnosed and untreated hytpothyroidism. I managed to find a psychiatrist who was very nice and helpful with some "talk" therapy, but it wasn't until three months ago that I saw a new doctor who diagnosed me with hypothyroidism. She said I had probably had it for ten years, based on my symptom history. She prefers to prescribe Armour thyroid so I've started on that and it's virtually like a weight lifted off my brain. My allergies are disappearing, too. I'm pretty peeved no doctor thought to test for it and blamed my tiredness and mental issues on my weight.

  • [...] posts that are well worth a read, and I found her series on depression particularly interesting. In Depression: Part 1, Scicurious explains why we should care about this disease: Right now, depression is thought to [...]

  • [...] posts that are well worth a read, and I found her series on depression particularly interesting. In Depression: Part 1, Scicurious explains why we should care about this disease: Right now, depression is thought to [...]

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